Oral Presentation The Joint Annual Scientific Meetings of the Endocrine Society of Australia and the Society for Reproductive Biology 2017

Pravastatin ameliorates feto-placental vascular defects, and fetal growth in a model of glucocorticoid excess (#75)

Caitlin Wyrwoll 1
  1. The University of Western Australia, Nedlands, WA, Australia

Environmental challenges in utero perturb placental function, fetal growth and alter subsequent adult health outcomes. The role of the feto- placental vasculature in modulating these processes is unclear. This imbalance in knowledge needs to be addressed in order to develop much needed diagnostic and therapeutic approaches for compromised pregnancies. Rodent models of decreased feto-placental vascularity exhibit fetal growth restriction and hinders fetal heart development. Recently, we have shown that in mice, impaired feto-placental vascularity can be restored via pravastatin administration. This in turn reverses the restricted fetal growth and cardiovascular development. We are currently working on understanding the development of feto-placental vascular structure and how this alters in vivo placental blood flow and function. Ultimately, this work highlights the importance of feto-placental vasculature in determining not just immediate fetal development but long term health and disease outcomes.