Technological innovation has transformed patterns of fertility globally, with lower fertility rates and improved perinatal outcomes.
However, the same period has seen older age at birth, increased use of assisted reproductive technologies, and epidemics of adverse lifestyle factors such as obesity.
Research on the impact of these factors on the reproductive health of contemporary women and the future health of their children is fragmented, giving rise to poorly focussed and inefficient interventions.
This talk integrates a series overlapping cohort studies drawn from the same population base to develop a synthetic lifecourse cohort to identify environmental factors that contribute to impaired infertility, adverse pregnancy outcomes after infertility treatment, and the consequences of treatment for the enduring health of the offspring.