Monday, 28th August The Joint Annual Scientific Meetings of the Endocrine Society of Australia and the Society for Reproductive Biology 2017

The conference acknowledges the support of

• Cardiac tissue injury and remodeling is dependent upon MR regulation of activation pathways in cardiac tissue macrophages - Jimmy Shen

• Premature ovarian insufficiency in the absence of Senataxin - Goutham Narayanan Subramanian
• The impact of macronutrient balance on the development of polycystic ovary syndrome (PCOS) traits - Valentina Rodriguez-Paris
• Preservation of female reproduction from cancer treatment through manipulation of NAD⁺ - Wing Hong Ho
• Double strand break DNA Repair occurs via non homologues end joining in mouse MII oocytes - Jacinta H Martin
• Cep55 couples proteolysis with anaphase and interkinesis in oocytes - Chenxi Zhou

• Characterisation of mouse epididymosomes reveals a complex molecular payload and a potential mechanism for modification of the sperm proteome and epigenome - Brett Nixon
• Mesenchymal cell radial intercalation is a major contributor to Wolffian/epididymal duct morphogenesis: Role of Protein Tyrosine Kinase 7.   - Barry T Hinton
• The protective roles of epididymal cysteine-rich secretory proteins (CRISPs) in male fertility - Jinghua Hu
• At coitus seminal fluid activates genes associated with cholesterol biosynthesis in the endometrium of the mouse - John E Schjenken
• Infection of the murine epididymis with uropathogenic E. coli causes ductal obstruction and fibrosis, which cannot be resolved by antibiotic treatment alone - Rukmali Wijayarathna

The conference acknowledges the support of

• Placental microRNA expression and renin-angiotensin system activity are regulated by oxygen - Anya L Arthurs
• Placental inflammation is associated with altered fetal immune responses at birth - Lisa F Stinson
• The prorenin receptor ((P)RR) and soluble prorenin receptor (s(P)RR) have roles in syncytiotrophoblast formation - Saije K Morosin
• High levels of HtrA4 observed in preeclamptic serum induce endothelial cell cycle arrest and senescence and inhibit endothelial progenitor cell differentiation for repair - Yao Wang

The conference acknowledges the support of

• Ghrelin-Reactive autoantibodies are elevated in children with Prader-Willi Syndrome compared to unaffected controls - Gabrielle Crisp
• Adolescent inhalant abuse induces an endocrine disorder analogous to adrenal insufficiency - Rose Crossin
• Characterising the physiology and therapeutic potential of inhibin A and B - Monica P Goney
• 3D bioengineered microtissues reveal key role of tumour microenvironment in early prostate carcinogenesis - Brooke A Pereira
• The lncRNA GHSROS mediates tumour growth and expression of genes associated with metastasis and adverse outcome - Patrick Thomas
• Glucocorticoid receptor-mediated signalling inhibits cell proliferation via repression of the V1 isoform of versican during mouse lung development - Kelly Short

• Podocalyxin derived from maternal endothelial cells is present in pregnant serum and significantly increased in early-onset preeclampsia - Guiying Nie
• Clomiphene citrate administration during the pre-implantation period results in fetal growth retardation in mice - Peck Yin Y Chin
• Depletion of regulatory T cells alters the uterine artery function during pregnancy and causes fetal growth restriction - Alison S Care
• Maternal protein restriction in mice reduces fetal growth and placental angiogenic gene expression in female but not male, fetuses. - Yutthapong TONGPOB
• Maternal weight at birth and risk of pregnancy complications - Prabha Andraweera
• Prophylactic treatment during pregnancy with a microbial-derived immunomodulator to protect mother and fetus against maternal bacterial infection induced complications. - Naomi M Scott

• Beneficial impact of a dietary supplement on sperm characteristics in mice fed high fat diet - Josephine Yu
• The role of mouse CRISP2 in regulating sperm motility via ion channel regulatory activity - Avinash Gaikwad
• Splicing up your sex life: Why men are failing to produce in the bedroom - Mark A Baker
• Use of modified DNA immunoprecipitation procedure to identify genomic regions vulnerable to oxidative DNA damage in human spermatozoa. - Shaun D Roman
• An essential function for a lonely SOX - Josephine Bowles
• LRGUK1 is required for manchette function, forming multiprotein complex with intracellular transportation proteins. - Hidenobu H.O Okuda

• Fast versus slow weight loss: head to head comparison of effects on body composition and muscle strength in postmenopausal women with obesity – the TEMPO diet trial - Radhika V Seimon
• SWITCH 1: Reduced risk of hypoglycaemia with insulin degludec vs. insulin glargine U100 in patients with type 1 diabetes – a randomised, double-blind, crossover trial - Gregory R Fulcher
• Persistent adiposity 2 years after cessation of androgen deprivation therapy in men with prostate cancer. - Stefan V. Milevski
• Use of temozolomide in a large cohort of patients with aggressive pituitary tumours - Ann McCormack
• Progressive impairment of testicular endocrine function in ageing men: testosterone and dihydrotestosterone decrease, and luteinising hormone increases, in men transitioning from the 8th to 9th decades of life. - Bu B Yeap
• Mutations in the HMGCS2 gene are associated with disorders of sex development - Stefan Bagheri-Fam

• Endocrine disorders in pregnancy - Carolyn Allan
• Update on hyperglycaemia in pregnancy - Louise Maple-Brown
• Management of thyroid disorders in pregnancy - Christine Houlihan

The conference acknowledges the support of

• The surprising role of zinc in oocyte maturation and embryo progression - Teresa Woodruff

• Genetics for endocrinologists - Roderick Clifton-Bligh

• RNA-based therapeutics: the new kid on the block. - Peter J Leedman
• Translation of a research discovery in prostate cancer with a gifted student, four patients and an international collaboration - Gail Risbridger
• Treatment of obesity is effective - why the barriers? - Ian Caterson

• Effect of testosterone treatment on adipokines and gut hormones in obese men on a hypocaloric diet - Mark Ng Tang Fui
• The effects of testosterone treatment on body composition in obese men are not sustained after cessation of therapy - Mark Ng Tang Fui
• The effect of vitamin D supplementation on faecal microbiome in vitamin D-deficient, overweight or obese adults: a randomised clinical trial    - Negar Naderpoor
• Glucocorticoid induced suppression of osteocalcin is associated with attenuated post-exercise insulin sensitivity and impaired skeletal muscle mTOR and insulin signaling in humans. - Itamar Levinger
• Cyproterone vs spironolactone as anti-androgen therapy for transgender females receiving oestradiol therapy. - Ada S. Cheung
• Effect of prednisolone and hyperinsulinaemia on bone turnover in patients with inflammatory arthritis - Morton G Burt
• ADT in prostate cancer patients: prevention of adverse effects using a 6-month home-based progressive resistance training program - Teresa Lam
• Serum 25-hydroxyvitamin D as a predictor of mortality and cardiovascular events: a 20 year study of a community-based cohort - Kun (Kathy) Zhu

The conference acknowledges the support of

• The role of the prorenin/(P)RR interaction in fetal membrane integrity - Sarah J Delforce
• Characterisation of 15 arachidonate lipoxygenase as a contributing factor to oxidative stress in human spermatozoa - Jessica LH Walters
• Macrophage regulation of vascular remodelling is required for placental development in mice - Holly M Groome
• Post-translational removal of α-DG-N is important for early stage endometrial cancer development - Sophea Heng
• The serine protease testisin and its role in functional maturation of equine spermatozoa - Aleona Swegen

The conference acknowledges the support of

• The role of bromodomain protein 4 on the pathophysiology of preeclampsia - Stella Liong
• Stem/progenitor cells contribute to luminal epithelial repair following endometrial breakdown in a mouse model of menses. - Fiona Cousins
• Morphological differences in uterine epithelial cells after ovarian hyperstimulation – ‘Receptive’ or ‘Non-Receptive’ at the time of implantation - Laura Lindsay

• The role of beta-cell Hif1α in the response of high fat diet-fed beta-TRAP mice to acute glucose challenge - Sing-Young Chen
• Effect of caloric-restriction and exercise on hypothalamic appetite-regulating peptides in the ewe - John-Paul Fuller-Jackson
• Insights from engraftable immunodeficient mouse models of hyperinsulinaemia - Michelle Maugham
• Metabolic and reproductive abnormalities in mice with impaired skeletal-mTORC1 function mirror a dietary restriction phenotype - Pawanrat Tangseefa
• Periconceptional alcohol exposure results in sex-specific alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring - Karen Moritz
• Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease - Craig A Harrison

• Transcriptome profiling of single prostate cancer cells following androgen deprivation - Ashlee Clark
• Thyroid cancers resected in patients with concurrent TSH-receptor stimulation have higher levels of sodium-iodide symporter (NIS) expression - Christopher Rowe
• Heteromerisation of the angiotensin II type 1 receptor and the bradykinin type 2 receptor - Elizabeth KM Johnstone
• Overview of emerging performance and image enhancing drugs (PIEDs) of concern in Australia - Lance Brooker
• Characterisation of a novel species-restricted putative hydroxysteroid dehydrogenase called HSD1L in the pituitary-gonadal axis - Spencer T Greatorex
• Loss of SLIRP is associated with poorer prognosis and increased invasion in colorectal cancer - Shane M Colley
• Hypoglycaemia secondary to the Warburg-effect - Flavian Joseph
• Delayed hyponatremia following transsphenoidal surgery for pituitary adenomas - Simon Rajaratnam
• The effect of an educational session on attitudes toward delivery of transgender healthcare by medical students and general practitioners in the Hunter region - Katie Wynne
• Bioavailable and free 25-hydroxyvitamin D and vitamin D binding protein in polycystic ovary syndrome: relationships with obesity and insulin resistance - Negar Naderpoor
• Brown adipose tissue thermogenesis in women with polycystic ovary syndrome - Soulmaz Shorakae
• High molecular weight adiponectin is inversely associated with sympathetic activity in polycystic ovary syndrome - Soulmaz Shorakae
• Long-term serum calcium levels, renal function, and bone mineral density in primary hyperparathyroidism: a comparison of medical and surgical therapy - John W.P. Wong
• An analysis of the baseline characteristics and outcomes, by responders and nonresponders, from the phase 3 study of (E7080) Lenvatinib in differentiated cancer of the thyroid (SELECT) - Louise Young
• Urine and serum sex steroids in testosterone (T)-treated female-to-male (F2M) transgender and hypogonadal men - Sasha Savkovic
• Retrospective review of 64 patients with amiodarone-induced thyrotoxicosis - Michelle Isaacs
• Within-day variability based on 9-point profiles correlates with risk of overall and nocturnal hypoglycaemia in adults with type 1 and type 2 diabetes - Roger Chen
• Testosterone for type 2 diabetes prevention in men: A 2-year multicentre, randomised, double-blind, placebo-controlled trial - Gary Wittert
• Effect of testosterone treatment on bone remodelling markers and bone density in obese dieting men in a randomized, placebo-controlled clinical trial - Mark Ng Tang Fui
• Sodium level on admission and in-hospital mortality  - Wenlin Cecilia Chi
• Comparing a telephone- and a group-delivered diabetes prevention program: characteristics of engaged and non-engaged postpartum mothers with a history of gestational diabetes. - Siew Lim
• Hyponatremia- How are we managing it ? - Antony Kurishingal Aloysius
• Adrenocorticotropic hormone stimulation in adrenal vein sampling – friend or foe? - Nicholas YN Chee
• Insulin sensitivity, 25-hydroxyvitamin D and phosphate levels and not calcium levels are determinants of bone mineral density in overweight and obese individuals.  - Negar Naderpoor
• Li Fraumeni Syndrome and phaeochromocytoma - Amanda Seabrook
• Clinical characterization of patients with Cushing’s disease from two Australian tertiary hospitals. - Angeline Shen
• Predictors of long term remission, relapse and non-resolution with anti-thyroid medication in Graves' disease in a Tasmanian population - James P Robinson
• Investigation and management of inpatient hyponatraemia. - Kathryn Berkman
• The relationship between objectively-assessed physical activity and bone mineral density in older adults differs by sex and is mediated by body weight - Lachlan B McMillan
• Pituitary function in patients taking oral or transdermal opioid analgesics for non-cancer pain - Andrea Lamprecht
• 24-hour blood pressure profile may distinguish primary aldosteronism from essential hypertension - Serena Menezes
• Clinical features of female to male (FTM) transgender. - Sarina Lim
• A retrospective audit of performance and image enhancing drug (PIED) use and associated biochemical and haematological abnormalities amongst visitors to a needle exchange clinic in Western Sydney - Matthew Luttrell
• Radioiodine for graves disease a 10 year retrospective cohort study - Erin Fanning
• Clinical audit in the use of low versus high dose radioactive iodine in thyroid cancer: a local viewpoint - Aditi Nevgi
• Audit of characteristics of patients with low serum alkaline phosphatase levels - Andrea Fernandes
• Motivation, willingness and engagement in healthy behaviours in overweight men at high risk of diabetes participating in the testosterone for type 2 diabetes prevention in men (T4DM) study - Tarryn Sohn
• Prevalence of secondary causes of bone loss in women treated with adjuvant endocrine therapy for breast cancer - Olivia Coleman
• A retrospective audit of secondary fracture prevention at Peninsula Health - Sylvia F Xu
• Elevated insulin like growth factor 1 in cushings disease - Katherine English
• Clinical characteristics of trans and gender diverse individuals attending specialist endocrinology clinics. - Olivia Ooi
• Decrease in number of men being commenced on androgen deprivation therapy for prostate cancer at a tertiary referral hospital over time. - Jennifer Yeh
• Outcomes of long-term surveillance of succinate dehydrogenase mutation carriers followed in a familial endocrine cancer clinic - Alice Y Hong
• Conundrum in Cushing’s: UFC measured concurrently on three methods - Nisa Sheriff
• Sperm cryopreservation to insure fertility for men having gonadotoxic treatment: single centre experience over 4 decades - Nandini Shankara Narayana
• Can the saline suppression test predict the subtype of primary aldosteronism? - Hikaru Hashimura
• Chicken or the egg: cortisol dysregulation is frequent but overt Cushing’s syndrome is rare in an unselected type 2 diabetes population   - Nisa Sheriff
• Increased prevalence of frequent hypoclycaemia and fracture in young adults with concomitant type 1 diabetes mellitus and coeliac disease - Eleanor P Thong
• Development of a simple method for reporting cortisol and aldosterone results and ratios after  adrenal vein sampling - Ailie B Connell
• Maternal circulating lipid species predict babies large for gestational age independent of GDM - Melina Bagala
• Glucose and insulin profiles during an oral glucose tolerance test (oGTT) are similar between fed and fasted states in a cohort of university students. - Lisa K Akison
• Body composition to estimate percentage fat mass: Comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students. - Lisa K Akison
• Primary hyperparathyroidism in multiple endocrine neoplasia type 1: clinical significance and threshold for intervention - Dahlia Davidoff
• Efficacy and safety of fast-acting insulin aspart are maintained over 52 weeks: comparison with insulin aspart in onset 1 - Stephen Twigg
• Improved glycaemic control with carbohydrate counting for adjustment of fast-acting insulin aspart versus insulin aspart in subjects with type 1 diabetes - Stephen Twigg
• Radioactive iodine (RAI) therapy for hyperthyroidism: An audit of safety and effectiveness. - Danish Mahmud
• The causes of deaths and adverse events in inpatients with Diabetes Insipidus. A suggested strategy for electronic prescribing and a change of name to Pituitary Insipidus to improve safety. - Malcolm Prentice
• A rare case of hypercalcemia associated with cryptococcal infection and immune reconstitution inflammatory syndrome with low 1, 25-dihydroxyvitamin D - Nely Shrestha Khatri
• Audit of inpatient glucose control in a regional Queensland hospital - Thomas J Ulahannan
• From renal salt-wasting to SIADH: a case report - Senthil Thillainadesan
• Chromosomes, hormones and gender: transsexualism in a patient with Klinefelter syndrome - Katie Wynne
• Clinical and laboratory aspects of the effects of danazol on adrenal and sex hormone levels - Meg Henze
• As clear as mud: an atypical case of primary hyperparathyroidism - Jessica Lai
• Vanishing acromegaly - Dev A Kevat
• Pharmacokinetics of testosterone administered to scrotal skin - Rakesh Iyer
• Sustained, successful treatment of diabetes in lipodystrophy by dapagliflozin  - Thomas J Ulahannan
• Central serous retinopathy: an uncommon presentation of Cushing’s syndrome. - Walter E Plehwe
• Acute hyponatraemic encephalopathy secondary to adjuvant cyclophosphamide for breast cancer - Thora Chai
• Hypophosphataemic osteomalacia induced by tenofovir disoproxil fumurate - Tamara Y Milder
• Jugulotympanic paraganglioma and thymoma co-occurrence in a patient with SDHA mutation - Kathryn Berkman
• Suspected parathyroid carcinoma staged with 18F-Fluorocholine PET CT. A case report. - MARCUS ASOKENDARAN
• To biopsy or not to biopsy - Bianca Nightingale
• A case of seriously sore back after Denosumab discontinuation - Yu-Chin Lo
• Diabetes mellitus: expect the unexpected? - Hui Yi HN Ng
• Recurrent minimal trauma fractures in an atypical case of tumour-induced osteomalacia - Christopher Muir
• Non-obstructive azoospermia: a case of sertoli cell only syndrome - Natassia Rodrigo
• Thyrotoxic periodic paralysis: an under-recognised complication of thyrotoxicosis - Senthil Thillainadesan
• An unusual case of panhypopituitarism and infundibulo-hypophyseal enlargement. - Uyen N Pham
• The eyes have it - Andrea Fernandes
• Limbal stem cell deficiency in a patient with autoimmune polyglandular syndrome type 1 - Kyaw Thura
• Addison's disease presenting with hypercalcaemia  - Kyaw Thura
• Acute hyponatraemia with an unexpected aetiology - Jane J Tellam
• Cetuximab induced hypocalcaemia, hypomagnesaemia and hypoparathyroidism - Shan Jiang
• Expanding the phenotype of the fumarate hydratase germline mutation familial cancer syndrome  - Veronica Boyle
• Two cases of adrenocortical carcinoma - Alice Y Hong
• A previously well young woman who developed central diabetes insipidus after influenza vaccination - Thomas H Chesterman
•  Management of metabolic complications after gastric bypass in type 1 diabetes - Thomas Ulahannan
• Close contact of an endocrinological kind - Deila Dedic
• A complex case of permanent hypoadrenalism with high dose glucocorticoid (HDGC) use for immune related adverse events (irAEs) of checkpoint inhibitors - Dilan Seneviratne Epa
• The molecular imaging of insulinomas - Josephine McCarthy
• The enigmatic triad of diabetic ketoacidosis, severe hyper-triglyceridaemia and acute pancreatitis: A case report and review of the literature. - Danish Mahmud
• Unusual patterns of endocrine irAEs in patients receiving checkpoint inhibitor immunotherapies - Jennifer Snaith
• Non-insulinoma pancreatogenous hypoglycaemia in adults (adult nesidioblastosis).  When distal pancreatectomy fails to effect improvement, consider using everolimus. - Yang Du
• Pseudopseudopseudohypoparathyroidism - Matti Gild
• A case of familial primary adrenal insufficiency, impaired spermatogenesis and hypogonadotropic hypogonadism - Anna Wood
• A case of severe post-prandial hypoglycaemia following gastric bypass surgery - Dilshani DJ Jayawardene
• A curious case of hypocalcaemia - Diana MacKay
• Sellar and suprasellar masses: pituitary metastasis as an important differential - Mina Mohammad Ebrahim
• Composite Pheochromocytoma: 2 cases - Matthew Luttrell
• Will this ever end? Recurrent hypoglycaemia due to insulinomatosis - Jennifer Snaith
• Immunotherapy induced endocrinopathies: the dilemmas of modern melanoma treatments. - Elizabeth George
• Severe pancreatic allograft associated hypoglycaemia captured on an ambulatory continuous glucose monitoring system - Elizabeth George
• Two for the price of one: unravelling a complex case of resistant hypertension. - Pieter M Jansen
• An unusual cause of headaches in an adolescent  - Eugenie S Lim
• The good the bad and the ugly of metastatic adrenocortical cancer - Katherine English
• Sella Dweller - Michele Bardin
• The great masquerader: complications of severe catecholamine excess - Brendan J Nolan
• Genetic Acromegaly: A tale of two tumours - Rahul Barmanray
• Transient diabetes insipidus in a postpartum woman with preeclampsia associated with residual placental vasopressinase activity - Natassia Rodrigo
• Precipitation of type 1 diabetes with anti-PD-1 immunotherapy - Ahmed Hussein
• Changing times: pituitary apoplexy - Deniz Kuzulugil
• Vanishing non functioning pituitary macroadenoma - Amy Harding
• Profound hypocalcaemia following Denosumab for metastatic prostate carcinoma; an under-recognised and potentially fatal complication - Thomas Chesterman
• Rapidly expanding Prolactinoma - Nele Lenders
• Malignant sarcoma after irradiation for an aggressive non-functioning pituitary adenoma - Anneke Graf
• Primary hyperparathyroidism in a young woman: Implications for genetic testing for CDC73 mutations   - Brigette Clarke
• Diabetes insipidus and pituitary stalk thickening: wading through the water and concentrating the evidence - Alicia Jones
• Managing thyroid storm in a patient with carbimazole-induced agranulocytosis - Krupali Bulsari
• A case of untreated Hypopituitarism: Effects and current challenges - Nithin Kolanu
• Investigating the impact of activin A on the epigenetic regulation of male fetal germ cells - Sarah C Moody
• Expression of L-Proline transporters in early embryo development - Tamara Treleaven
• Extracellular matrix (ECM) and Wnt signalling nexus in human uterine leiomyomas - Yi-An Ko
• Evaluating the expression levels of Toll Like Receptor 9 (TLR 9) in women with endometriosis and its comparison with normal endometrium - Ali A Aflatounian
• The potential role of VEGF111 and other VEGF isoforms in the development of endometriosis - Kevin Danastas
• Anatomy and physiology of the male reproductive tract in the spiny mouse (Acomys cahirinus) across the lifespan. - Jared Mamrot
• Cyclin B1 is controlled at the translational level in small oocytes from pre-antral follicles - Zhe Wei
• Potential involvement of Sirt1–PGC-1α–Sirt3 modulating mitochondrial NADPH–NADH balance in association with FSH and TGFβ1-induced P450scc complex activity in ovarian granulosa cells - Yu-Hsin Peng
• Increased anxious behaviour during the premenstrual phase in the spiny mouse - Nadia Bellofiore
• The response in Kiss1r KO mice to peripheral ghrelin or leptin administration - Julie-Ann P De Bond
• Identification of a placental transthyretin receptor and its role in placental transfer of transthyretin and thyroid hormone - Kerry Richard
• The duration of sexual relationship and its effects on adverse pregnancy outcomes - Prabha Andraweera
• Crucial role of P2X7 receptor-pannexin1 in FSH and TGFß1 regulation of ovarian steroidogenesis - Wei-Ling Fang
• Effect of ginseng extract on sperm characteristics in merino rams  - Tayler Catherine Kent
• Whole body heating induces oxidative stress and DNA fragmentation in the male germ line - Brendan Houston
• The effects of experimental cryptorchidism on spermatogenesis and inhibin-related protein production in the adult rat - Rashid Aldahhan
• The role of CBE1 (ciliated bronchial epithelium 1) during spermatogenesis   - Christiane Pleuger
• Causes and consequences of oxidative damage in the male germ line - Geoffry N De Iuliis
• Stage-specific localisation of keratin intermediate filaments in uterine epithelial cells during normal pregnancy and ovarian hyperstimulation in the rat - Chad L. Moore
•   Identifying roles for the endometriosis risk gene vezatin in human endometrium   - Premila Paiva
• Expression of focal adhesion-associated proteins during early pregnancy for indicator of metastatic potential - Leigh Nicholson
• MicroRNA-155 deficiency increases lesion development in a mouse model of endometriosis - Kavita Panir
• Survey on feeding managements and reproductive status of different goat breeds in Peninsular Malaysia - Mashitah Shikh Maidin

The conference acknowledges the support of